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Literature summary extracted from

  • Li-Hawkins, J.; Lund, E.G.; Bronson, A.D.; Russell, D.W.
    Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol (2000), J. Biol. Chem., 275, 16543-16549.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.26
-
 Homo sapiens
1.14.14.26
-
 Mus musculus
1.14.14.29
-
 Mus musculus
1.14.14.29
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.26 Homo sapiens
-
-
-
1.14.14.26 Mus musculus Q9JKJ9
-
-
1.14.14.29 Homo sapiens
-
-
-
1.14.14.29 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.26 liver
-
 Homo sapiens
-
1.14.14.26 liver sexually dimorphic expression pattern, higher expression in female than in male Mus musculus
-
1.14.14.29 liver higher activity in male than in female Mus musculus
-
1.14.14.29 liver higher activity in male than in female Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.26 (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 activity is largely restricted to 24-hydroxycholesterol Homo sapiens (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
-
 ?
1.14.14.26 (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 activity is largely restricted to 24-hydroxycholesterol Mus musculus (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
-
 ?
1.14.14.29 22-hydroxycholesterol + NADPH + H+ + O2
-
 Mus musculus 7alpha,22-dihydroxycholesterol + NADP+ + H2O
-
 ?
1.14.14.29 24,25-epoxycholesterol + NADPH + H+ + O2
-
 Mus musculus 7alpha,hydroxy-24,25-epoxycholesterol + NADP+ + H2O
-
 ?
1.14.14.29 24-hydroxycholesterol + NADPH + H+ + O2
-
 Mus musculus 7alpha,24-dihydroxycholesterol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 substrates in descending order of activity: cholest-5-ene-3beta,25-diol, cholest-5-ene-3beta,27-diol, 24,25-epoxycholesterol, 22-hydroxycholesterol, 24-hydroxycholesterol Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
 Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.26 24-hydroxycholesterol 7alpha-monooxygenase
-
 Homo sapiens
1.14.14.26 24-hydroxycholesterol 7alpha-monooxygenase
-
 Mus musculus
1.14.14.26 Cyp39a1
-
 Homo sapiens
1.14.14.26 Cyp39a1
-
 Mus musculus
1.14.14.26 CYP39A1 oxysterol 7alpha-hydroxylase
-
 Homo sapiens
1.14.14.26 CYP39A1 oxysterol 7alpha-hydroxylase
-
 Mus musculus
1.14.14.29 CYP7B1
-
 Mus musculus
1.14.14.29 CYP7B1
-
 Homo sapiens